Beneficial to mental and emotional health, B-complex vitamins need to be replenished daily. During a study, adults ages 50 years and older who reported experiencing depression were given a combination of antidepressant medication, vitamin B12, folic acid and vitamin B6 over a year. Participants were monitored for changes and found that remission of symptoms were achieved by 75.8% and 85.5% after one year.  Results also showed a significant reduction in the risk of relapse among participants who took the B-vitamins. Researchers concluded that, while B vitamins did not increase short-term effectiveness of treatments, they did see improvement in antidepressant response after continued treatment.